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Aromatase expression in the cerebellum of the dog infected with canine distemper virus.

Authors
  • Yarim, Murat
  • Gulbahar, Mustafa Yavuz
  • Guvenc, Tolga
  • Karahan, Siyami
  • Harada, Nobuhiro
  • Kabak, Yonca Betil
  • Karayigit, Mehmet Onder
Type
Published Article
Journal
Berliner und Münchener tierärztliche Wochenschrift
Publication Date
Jan 01, 2010
Volume
123
Issue
7-8
Pages
301–306
Identifiers
PMID: 20690542
Source
Medline
License
Unknown

Abstract

Aromatase is the enzyme that catalyzes the biosynthesis of estrogens. It is implicated in neuroprotection.The present study investigated aromatase expression in the cerebellum of dogs infected with canine distemper virus (CDV), a disease characterized by demyelination in the white matter of the cerebellum. The presence of CDV infection was confirmed on the basis of histopathology and immunohistochemical localization of CDV antigen in glial cells of the white matter.The number of aromatase immunoreactive astrocytes were significantly (p < 0.05) higher in CDV-infected dogs compared to control dogs. The results suggest that astrocytes respond to invasion and persistence of CDV by means of increased estrogen production.The results also suggest that the high level of estrogen expression is maintained similarly throughout all stages of the disease since the number of aromatase immunoreactive astrocytes did not vary during the different stages of CDV infection.

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