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Aromatase in the brain: not just for reproduction anymore.

Authors
  • Garcia-Segura, L M
Type
Published Article
Journal
Journal of Neuroendocrinology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Jun 01, 2008
Volume
20
Issue
6
Pages
705–712
Identifiers
DOI: 10.1111/j.1365-2826.2008.01713.x
PMID: 18601693
Source
Medline
License
Unknown

Abstract

Aromatase, the enzyme that synthesises oestrogens from androgen precursors, is expressed in the brain, where it has been classically associated with the regulation of neuroendocrine events and behaviours linked with reproduction. Recent findings, however, have revealed new unexpected roles for brain aromatase, indicating that the enzyme regulates synaptic activity, synaptic plasticity, neurogenesis and the response of neural tissue to injury, and may contribute to control nonreproductive behaviours, mood and cognition. Therefore, the function of brain aromatase is not restricted to the regulation of reproduction as previously thought.

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