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An 'Arms Race' between the Nonsense-mediated mRNA Decay Pathway and Viral Infections.

Authors
  • Leon, Kristoffer1
  • Ott, Melanie2
  • 1 J. David Gladstone Institutes, United States; Department of Medicine, University of California, San Francisco, United States. , (United States)
  • 2 J. David Gladstone Institutes, United States; Department of Medicine, University of California, San Francisco, United States. Electronic address: [email protected] , (United States)
Type
Published Article
Journal
Seminars in Cell and Developmental Biology
Publisher
Elsevier
Publication Date
Mar 01, 2021
Volume
111
Pages
101–107
Identifiers
DOI: 10.1016/j.semcdb.2020.05.018
PMID: 32553580
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The Nonsense-mediated mRNA Decay (NMD) pathway is an RNA quality control pathway conserved among eukaryotic cells. While historically thought to predominantly recognize transcripts with premature termination codons, it is now known that the NMD pathway plays a variety of roles, from homeostatic events to control of viral pathogens. In this review we highlight the reciprocal interactions between the host NMD pathway and viral pathogens, which have shaped both the host antiviral defense and viral pathogenesis. Copyright © 2020 Elsevier Ltd. All rights reserved.

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