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Arginine 54 and Tyrosine 118 residues of {alpha}A-crystallin are crucial for lens formation and transparency.

Authors
Type
Published Article
Journal
Investigative Ophthalmology & Visual Science
0146-0404
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Publication Date
Volume
47
Issue
7
Pages
3004–3010
Identifiers
PMID: 16799046
Source
Medline
License
Unknown

Abstract

This work demonstrates that different regions of alphaA-crystallin mediate distinct functions in vivo. These two mutant mouse lines provide useful animal models for further investigating the multiple roles of alphaA-crystallin in the lens.

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