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Arecoline plays dual role on adrenal function and glucose-glycogen homeostasis under thermal stress in mice.

Authors
  • Dasgupta, Romi1
  • Saha, Indraneel2
  • Ray, Prajna Paramita3
  • Maity, Aniruddha1
  • Pradhan, Debajoyti1
  • Sarkar, Hari Prasad4
  • Maiti, B R1
  • 1 Department of Zoology, University of Calcutta, Calcutta, India. , (India)
  • 2 Department of Zoology, Sarsuna College, Calcutta, India. , (India)
  • 3 Department of Zoology, Bangabasi College, Calcutta, India. , (India)
  • 4 Department of Zoology, Vidyasagar University, West Midnapore, India. , (India)
Type
Published Article
Journal
Archives of physiology and biochemistry
Publication Date
Jul 01, 2020
Volume
126
Issue
3
Pages
214–224
Identifiers
DOI: 10.1080/13813455.2018.1508238
PMID: 30318934
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Arecoline has biomedical importance, but it has untoward side effects on endocrine functions. The aim is to investigate its role on adrenal activity under thermal stress by ultrastructural and hormonal parameters in mice. Cold (4 °C) or heat (37 °C) stress, or arecoline (10 mg/kg body wt), each for 7 days in cold or heat stress stimulated adrenocortical activity ultrastructurally with an elevation of corticosterone level. Adrenomedullary activity was suppressed in cold stress with depletion of catecholamine levels. In heat stress, adrenomedullary activity was stimulated ultrastructurally with an elevation of catecholamine levels. Arecoline treatment alone, or in cold or heat stress suppressed adrenomedullary activity, judged by ultrastructural and hormonal parameters. Arecoline treatment caused hypoglycemia with an elevation of glycogen level, but cold or heat stress, or arecoline treatment in thermal stress caused hyperglycemia, with a fall in glycogen profile. Thus, arecoline in thermal stress plays a dual role on adrenal function and glucose-glycogen homeostasis in mice.

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