Affordable Access

Publisher Website

The Architecture of Idiotypic Networks: Percolation and Scaling Behaviour

  • Brede, Markus
  • Behn, Ulrich
Publication Date
Apr 03, 2001
Submission Date
Jun 07, 2000
DOI: 10.1103/PhysRevE.64.011908
arXiv ID: physics/0006015
External links


We investigate a model where idiotypes (characterizing B-lymphocytes and antibodies of an immune system) and anti-idiotypes are represented by complementary bitstrings of a given length d allowing for a number of mismatches (matching rules). In this model, the vertices of the hypercube in dimension d represent the potential repertoire of idiotypes. A random set of (with probability p) occupied vertices corresponds to the expressed repertoire of idiotypes at a given moment. Vertices of this set linked by the above matching rules build random clusters. We give a structural and statistical characterisation of these clusters - or in other words - of the architecture of the idiotypic network. Increasing the probability p one finds at a critical p a percolation transition where for the first time a large connected graph occures with probability one. Increasing p further, there is a second transition above which the repertoire is complete in the sense that any newly introduced idiotype finds a complementary anti-idiotype. We introduce structural characteristics such as the mass distributions and the fragmentation rate for random clusters, and determine the scaling behaviour of the cluster size distribution near the percolation transition, including finite size corrections. We find that slightly above the percolation transition the large connected cluster (the central part of the idiotypic network) consists typically of one highly connected part and a number of weakly connected constituents and coexists with a number of small, isolated clusters. This is in accordance with the picture of a central and a peripheral part of the idiotypic network and gives some support to idealized architectures of the central part used in recent dynamical mean field models.

Report this publication


Seen <100 times