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Arachidonic Acid Metabolites in Cardiovascular and Metabolic Diseases

Authors
  • Sonnweber, Thomas
  • Pizzini, Alex
  • Nairz, Manfred
  • Weiss, Günter
  • Tancevski, Ivan
Publication Date
Oct 23, 2018
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

Lipid and immune pathways are crucial in the pathophysiology of metabolic and cardiovascular disease. Arachidonic acid (AA) and its derivatives link nutrient metabolism to immunity and inflammation, thus holding a key role in the emergence and progression of frequent diseases such as obesity, diabetes, non-alcoholic fatty liver disease, and cardiovascular disease. We herein present a synopsis of AA metabolism in human health, tissue homeostasis, and immunity, and explore the role of the AA metabolome in diverse pathophysiological conditions and diseases.

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