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Aqueous Extract of Gynura Bicolor Attenuated Hepatic Steatosis, Glycative, Oxidative, and Inflammatory Injury Induced by Chronic Ethanol Consumption in Mice.

Authors
  • Yin, Mei-Chin1, 2
  • Wang, Zhi-Hong1
  • Liu, Wen-Hu3
  • Mong, Mei-Chin1
  • 1 Dept. of Food Nutrition and Health Biotechnology, Asia Univ., Taichung City, Taiwan. , (Taiwan)
  • 2 Dept. of Medical Research, China Medical Univ. Hospital, China Medical Univ., Taichung City, Taiwan. , (China)
  • 3 Dept. of Nutrition, Chung Shan Medical Univ., Taichung City, Taiwan. , (Taiwan)
Type
Published Article
Journal
Journal of Food Science
Publisher
Wiley (Blackwell Publishing)
Publication Date
Nov 01, 2017
Volume
82
Issue
11
Pages
2746–2751
Identifiers
DOI: 10.1111/1750-3841.13930
PMID: 29023845
Source
Medline
Keywords
License
Unknown

Abstract

Gynura bicolor leaf aqueous extract (GAE) is rich in phytochemicals including phenolic acids, flavonoids, carotenoids, and anthocyanins. Effects of GAE upon hepatic injury in mice with chronic ethanol intake were examined. Lieber-DeCarli liquid diet with ethanol was used to induce hepatic lipid accumulation, oxidative, glycative, and inflammatory injury. GAE at 0.25% or 0.5% was added in feeds, and supplied to mice consumed Lieber-DeCarli liquid diet with ethanol for 6 wk. Blood and liver were collected for analyses. Results showed that ethanol increased plasma and hepatic triglyceride and cholesterol content, and affected plasma levels of insulin, adiponectin, leptin, and ghrelin. GAE at both doses decreased lipid accumulation, and at high dose improved hormones abnormality. Histological data revealed that GAE supplement mitigated hepatic lipid deposit. Ethanol increased plasma Nε -(carboxyethymethyl)-lysine and pentosidine levels. GAE at high doses lowered those glycative factors. Ethanol depleted glutathione content, increased CYP2E1 activity and reactive oxygen species production, and reduced the activity of glutathione peroxide, glutathione reductase and catalase in liver. GAE supplement at both doses reversed these alterations and attenuated hepatic oxidative stress. GAE supplement also at both doses decreased hepatic inflammatory cytokines release in ethanol treated mice. These findings support that leaves of G. bicolor is a functional food with liver protective activities against ethanol.

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