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AQUA and FISH analysis of HER-2/neu expression and amplification in a small cell lung carcinoma tissue microarray.

Authors
  • Giltnane, J M
  • Murren, J R
  • Rimm, D L
  • King, B L
Type
Published Article
Journal
Histopathology
Publication Date
Aug 01, 2006
Volume
49
Issue
2
Pages
161–169
Identifiers
PMID: 16879393
Source
Medline
License
Unknown

Abstract

The lack of gene amplification and robust HER-2/neu protein expression in SCLC tumour cells in this series does not suggest a prominent role for the HER-2/neu gene in SCLC tumour progression and does not support the general applicability of targeted immunotherapy with trastuzumab to this malignancy.

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