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Aptamer based photoelectrochemical determination of tetracycline using a spindle-like [email protected] nanocomposite

Authors
  • Zhang, Xiaoping
  • Zhang, Ruirui
  • Yang, Aijun
  • Wang, Qin
  • Kong, Rongmei
  • Qu, Fengli
Publication Date
Nov 01, 2017
Source
Institutional Repository of Institute of Process Engineering, CAS (IPE-IR)
Keywords
License
Unknown
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Abstract

<p> The authors have synthesized spindle-like ZnO nanorods closely anchored to CdS nanoparticles (NPs) placed on gold NPs ([email protected]). It is shown that the [email protected] nanocomposite can serve as a photoactive material for use in photoelectrochemical (PEC) detection by efficiently absorbing light and then promoting electron transfer. A visible light-driven PEC detection platform for tetracycline (TET) was fabricated by placing the nanocomposite on an ITO and immobilizing the TET-binding aptamer as biorecognition element. PEC can be quantified by applying a bias potential of + 0.4 V (vs. SCE) and visible light irradiation. The aptamer on the electrode specifically captures the TET present in the solution to produce a restored photocurrent signal through the reaction between the captured TET and the photogenerated holes. The electrode has a linear response in the 50 to 200 nM TET concentration range, with a 4.5 nM detection limit (at an S/N ratio of 3). In our perception, this novel PEC detection strategy based on ZnO-[email protected] nanocomposite demonstrated an ultrasensitive method for TET detection with high selectivity and good stability.</p>

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