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Approaches to identify and characterize microProteins and their potential uses in biotechnology

Authors
  • Bhati, Kaushal Kumar1, 2
  • Blaakmeer, Anko1, 2
  • Paredes, Esther Botterweg1, 2
  • Dolde, Ulla1, 2
  • Eguen, Tenai1, 2
  • Hong, Shin-Young1, 2
  • Rodrigues, Vandasue1, 2
  • Straub, Daniel1, 2
  • Sun, Bin1, 2
  • Wenkel, Stephan1, 2
  • 1 University of Copenhagen, Department of Plant and Environmental Sciences, Thorvaldsensvej 40, Frederiksberg C, 1871, Denmark , Frederiksberg C (Denmark)
  • 2 University of Copenhagen, Copenhagen Plant Science Centre, Thorvaldsensvej 40, Frederiksberg C, 1871, Denmark , Frederiksberg C (Denmark)
Type
Published Article
Journal
Cellular and Molecular Life Sciences
Publisher
Springer-Verlag
Publication Date
Apr 18, 2018
Volume
75
Issue
14
Pages
2529–2536
Identifiers
DOI: 10.1007/s00018-018-2818-8
Source
Springer Nature
Keywords
License
Green

Abstract

MicroProteins are small proteins that contain a single protein domain and are related to larger, often multi-domain proteins. At the molecular level, microProteins act by interfering with the formation of higher order protein complexes. In the past years, several microProteins have been identified in plants and animals that strongly influence biological processes. Due to their ability to act as dominant regulators in a targeted manner, microProteins have a high potential for biotechnological use. In this review, we present different ways in which microProteins are generated and we elaborate on techniques used to identify and characterize them. Finally, we give an outlook on possible applications in biotechnology.

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