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Approach to resistant gram-negative bacterial pulmonary infections in patients with cystic fibrosis.

Authors
  • Chernish, Robert N
  • Aaron, Shawn D
Type
Published Article
Journal
Current opinion in pulmonary medicine
Publication Date
Nov 01, 2003
Volume
9
Issue
6
Pages
509–515
Identifiers
PMID: 14534404
Source
Medline
License
Unknown

Abstract

Therapy for antibiotic-resistant bacterial infections in cystic fibrosis involves the use of new laboratory methods (synergy testing or multiple-combination bactericidal testing) to optimize antibiotic treatment strategies. Clinical trials are required to address whether treatment guided by susceptibility testing improves clinical outcomes. Future novel approaches will likely include drugs that can disrupt bacterial biofilm formation and the use of cationic peptide antimicrobial compounds.

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