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[Contribution of chromosomal microarray analysis by a multidisciplinary prenatal diagnosis center].

Authors
  • Bartholmot, C1
  • Mousty, E2
  • Grosjean, F2
  • Petrov, Y2
  • Khau Van Kien, P2
  • Chiesa, J2
  • Letouzey, V2
  • 1 CHU Caremeau, place du Professeur-Robert-Debre, 30000 Nimes, France. Electronic address: [email protected] , (France)
  • 2 CHU Caremeau, place du Professeur-Robert-Debre, 30000 Nimes, France. , (France)
Type
Published Article
Journal
Gynecologie, obstetrique, fertilite & senologie
Publication Date
Jan 01, 2017
Volume
45
Issue
7-8
Pages
400–407
Identifiers
DOI: 10.1016/j.gofs.2017.06.001
PMID: 28711366
Source
Medline
Keywords
Language
French
License
Unknown

Abstract

Chromosomal analysis by array CGH is a cytogenetic technique that has opened its application to prenatal diagnosis in recent years. The main objective of the study was to analyze the contribution for couples using chromosomal analysis by array CGH in a CPDPN. A retrospective cohort study was conducted in 2015 in a CPDPN. All the patients with array CGH analysis were included in the study. The analysis indications were CN≥3.5mm, ultrasound signs, intra-uterine growth retardation and fetal deaths. Data were collected in the prenatal diagnosis and genetic records. In total, 155 patients underwent analysis by array CGH, which corresponds to 36% of patients with invasive sampling indication. Fifteen CGH analysis were positive which represents 9.6% of indications. None of those diagnoses was possible with standard karyotype. These positive results have changed the outcome of pregnancy and what to do for a future pregnancy in 54% of cases. Array CGH enables a diagnostic gain despite a delicate interpretation and changes taking care of patients in future pregnancies. These results should be confirmed in a prospective multicenter study. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

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