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Application of photon correlation spectroscopy as a technique for detecting culture contamination.

Authors
Type
Published Article
Journal
Biotechnology and bioengineering
Publication Date
Volume
38
Issue
8
Pages
929–940
Identifiers
PMID: 18600849
Source
Medline
License
Unknown

Abstract

The application of photon correlation spectroscopy (PCS) to detect culture contamination in chemostats was studied. It was found that the presence of a given particle size in a population of particles of a different size could be detected, but this ability was strongly dependent on particles of a different size could be detected, but this ability was strongly dependent on particle size difference and was most sensitive when contaminants are larger than the host. The inherent polydisparity of actively growing and dividing microbial cells negates any advantage in the use of multi-angle PCS to detect contaminants.

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