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Application of metabolomics for revealing the interventional effects of functional foods on metabolic diseases.

Authors
  • Fu, Jia1
  • Zhang, Le-Le1
  • Li, Wei1
  • Zhang, Yan1
  • Zhang, Yamei2
  • Liu, Fang3
  • Zou, Liang4
  • 1 School of Basic Medical Sciences, Chengdu University, Chengdu 610106, China. , (China)
  • 2 Clinical Genetics Laboratory, Affiliated Hospital & Clinical Medical College of Chengdu University, Chengdu 610081, China. , (China)
  • 3 Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai 201203, China. Electronic address: [email protected] , (China)
  • 4 Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural Affairs, Sichuan Engineering & Technology Research Center of Coarse Cereal Industrialization, School of Food and Biological Engineering, Chengdu University, Chengdu 610106, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Food chemistry
Publication Date
Jan 15, 2022
Volume
367
Pages
130697–130697
Identifiers
DOI: 10.1016/j.foodchem.2021.130697
PMID: 34365248
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Metabolomics is an important branch of systems biology, which can detect changes in the body's metabolism before and after the intervention of functional foods, identify effective metabolites, and predict the interventional effects and the mechanism. This review summarizes the latest research outcomes regarding interventional effects of functional foods on metabolic diseases via metabolomics analysis. Since metabolomics approaches are powerful strategies for revealing the changes in bioactive compounds of functional foods during processing and storage, we also discussed the effects of these parameters on functional food metabolites using metabolomics approaches. To date, a number of endogenous metabolites related to the metabolic diseases after functional foods intervention have been discovered. Unfortunately, the mechanisms of metabolic disease-related molecules are still unclear and require further studies. The combination of metabolomics with other omics technologies could further promote its ability to fully understand the precise biological processes of functional food intervention on metabolic diseases. Copyright © 2021 Elsevier Ltd. All rights reserved.

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