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[Application of inhaled nitric oxide in extreme preterm neonates with with BPD].

Authors
  • Radulova, P
  • Slancheva, B
Type
Published Article
Journal
Akusherstvo i ginekologii︠a︡
Publication Date
Jan 01, 2014
Volume
53
Issue
4
Pages
46–50
Identifiers
PMID: 25510071
Source
Medline
License
Unknown

Abstract

Prolonged inhaled nitric oxide (iNO) from birth in preterm neonates with BPD improves endogenous surfactant function as well as lung growth, angiogenesis, and alveologenesis. As a result there is a reduction in the frequency of the "new" form of BPD in neonates under 28 weeks of gestation and birth weight under 1000 gr. Delivery of inhaled nitric oxide is a new method of prevention of chronic lung disease. According to a large number of randomized trials iNO in premature neonates reduces pulmonary morbidity and leads to a reduction of the mortality in this population of patients. This new therapy does not have serious side effects.

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