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Application of the 1-microsecond pulsed-dye laser to the treatment of experimental cerebral vasospasm.

Authors
  • Teramura, A
  • Macfarlane, R
  • Owen, C J
  • de la Torre, R
  • Gregory, K W
  • Birngruber, R
  • Parrish, J A
  • Peterson, J W
  • Zervas, N T
Type
Published Article
Journal
Journal of neurosurgery
Publication Date
Aug 01, 1991
Volume
75
Issue
2
Pages
271–276
Identifiers
PMID: 2072166
Source
Medline
License
Unknown

Abstract

Laser energy of 480 nm was applied in 1-microsecond pulses varying between 2.2 and 10 mJ to in vitro and in vivo models of cerebral vasospasm. First, the pulsed-dye laser was applied intravascularly via a 320-microns fiber to basilar artery segments from six dogs. The segments were mounted in a vessel-perfusion apparatus and constricted to, on average, 70% of resting diameter by superfusion with dog hemolysate. Immediate increase in basilar artery diameter occurred to a mean of 83% of control. In a second model, the basilar artery was exposed transclivally in the rabbit. In three normal animals, superfusion of the artery with rabbit hemolysate resulted in a reduction of mean vessel diameter to 81% of control. Following extravascular application of the laser, vessels returned to an average of 106% of the resting state. In six rabbits, the basilar artery was constricted by two intracisternal injections of autologous blood. 3 days apart. Two to 4 days after the second injection, the basilar artery was exposed. Extravascular laser treatment from a quartz fiber placed perpendicular to the vessel adventitia resulted in an immediate 53% average increase in caliber to an estimated 107% of control. No reconstriction was observed over a period of up to 5 hours. Morphologically, damage to the arterial wall was slight. This preliminary investigation suggests that the 1-microsecond pulsed-dye laser may be of benefit in the treatment of cerebral vasospasm.

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