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An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages

Authors
  • de Vasconcelos, Nathalia Moraes1, 2
  • Van Opdenbosch, Nina1, 2, 3
  • Van Gorp, Hanne1, 2
  • Martín-Pérez, Rosa3
  • Zecchin, Annalisa3
  • Vandenabeele, Peter2, 4, 5
  • Lamkanfi, Mohamed1, 2, 3
  • 1 Department of Internal Medicine and Pediatrics, Ghent University, 9052 Ghent, Belgium
  • 2 VIB Center for Inflammation Research, 9052 Ghent, Belgium
  • 3 & Johnson, Beerse 2340, Belgium
  • 4 Department of Biomedical Molecular Biology, Ghent University, Ghent 9052, Belgium
  • 5 Methusalem program, Ghent University, Ghent 9052, Belgium
Type
Published Article
Journal
Cell Reports
Publisher
Elsevier
Publication Date
Jul 28, 2020
Volume
32
Issue
4
Identifiers
DOI: 10.1016/j.celrep.2020.107959
PMID: 32726624
PMCID: PMC7408007
Source
PubMed Central
Keywords
License
Unknown

Abstract

de Vasconcelos et al. demonstrate that an apoptotic cascade is initiated in macrophages undergoing inflammasome-mediated pyroptosis. Caspase-1 and caspase-8 initiate the downstream activation of apoptotic caspase-3 and caspase-7, leading to cleavage of apoptotic markers during pyroptosis. This caspase network explains why inflammasome-activated GSDMD−/− and Casp1−/− cells undergo apoptosis.

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