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Apoptosis versus necrosis during cold storage and rewarming of human renal proximal tubular cells.

Authors
  • 1
  • 1 Department of Medicine, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216-4505, USA.
Type
Published Article
Journal
Transplantation Journal
0041-1337
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Volume
72
Issue
5
Pages
798–804
Identifiers
PMID: 11571440
Source
Medline
License
Unknown

Abstract

Our study in human tubular cells provides evidence that cold storage per se does not result in apoptosis, but is primarily necrotic. However, rewarming is associated with significant apoptosis in the presence of ongoing necrosis, speculatively due to the activation of the apoptotic enzymic process of sublethally injured cells. Inclusion of antioxidants in the storage solution confers protection against both cold storage and rewarming-induced necrosis and apoptosis.

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