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Apoptosis of murine melanoma B16-BL6 cells induced by quercetin targeting mitochondria, inhibiting expression of PKC-alpha and translocating PKC-delta.

Authors
  • Zhang, Xian-Ming
  • Chen, Jia
  • Xia, Yu-Gui
  • Xu, Qiang
Type
Published Article
Journal
Cancer chemotherapy and pharmacology
Publication Date
Mar 01, 2005
Volume
55
Issue
3
Pages
251–262
Identifiers
PMID: 15538571
Source
Medline
License
Unknown

Abstract

These results indicate that quercetin induced apoptosis of murine melanoma B16-BL6 cells by injuring their mitochondria, increasing the activity of caspase-3, inhibiting the expression of Bcl-2 and PKC-alpha, and inducing the translocation of PKC-delta. Doxorubicin inhibited these effects of quercetin by blocking the decreased expression of PKC-alpha induced by quercetin while PMA increased these effects by enhancing the translocation of PKC-delta induced by quercetin.

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