Affordable Access

Apoptosis in neural crest cells by functional loss of APC tumor suppressor gene

Authors
  • Sumitaka Hasegawa
  • Tomoyuki Sato
  • Hiroshi Akazawa
  • Hitoshi Okada
  • Akiteru Maeno
  • Masaki Ito
  • Yoshinobu Sugitani
  • Hiroyuki Shibata
  • Jun-ichi Miyazaki
  • Motoya Katsuki
  • Yasutaka Yamauchi
  • Ken-ichi Yamamura
  • Shigeru Katamine
  • Tetsuo Noda
Publisher
The National Academy of Sciences
Publication Date
Dec 26, 2001
Source
PMC
Keywords
Disciplines
  • Biology
License
Unknown

Abstract

Apc is a gene associated with familial adenomatous polyposis coli (FAP) and its inactivation is a critical step in colorectal tumor formation. The protein product, adenomatous polyposis coli (APC), acts to down-regulate intracellular levels of β-catenin, a key signal transducer in the Wnt signaling. Conditional targeting of Apc in the neural crest of mice caused massive apoptosis of cephalic and cardiac neural crest cells at about 11.5 days post coitum, resulting in craniofacial and cardiac anomalies at birth. Notably, the apoptotic cells localized in the regions where β-catenin had accumulated. In contrast to its role in colorectal epithelial cells, inactivation of APC leads to dysregulation of β-catenin/Wnt signaling with resultant apoptosis in certain tissues including neural crest cells.

Report this publication

Statistics

Seen <100 times