Affordable Access

Apoptosis and fibrosis of vascular smooth muscle cells in aortic dissection: an immunohistochemical study

Authors
  • Lee, Jae Hoon1
  • Kim, Junmo2
  • Lee, Sun-Jae3
  • Kim, Young-Ah3
  • Maeng, Young-In3
  • Park, Kwan-Kyu3
  • 1 Division of Vascular and Endovascular Surgery, Department of Surgery, College of Medicine, Catholic University of Daegu, Daegu, Republic of Korea
  • 2 Department of Forensic Medicine, National Forensic Service, Republic of Korea
  • 3 Department of Pathology, College of Medicine, Catholic University of Daegu, Daegu, Republic of Korea
Type
Published Article
Journal
International journal of clinical and experimental pathology
Publication Date
Aug 01, 2020
Volume
13
Issue
8
Pages
1962–1969
Identifiers
PMID: 32922591
PMCID: PMC7476953
Source
PubMed Central
Keywords
License
Unknown

Abstract

Aortic dissection (AD) is a fatal disease characterized by a ruptured intima that leads to the complete rupture of the aorta. The aim of this study is to examine the immunohistochemical expression of inflammation/fibrosis-associated chemical mediators in AD patients. Surgical specimens of aortic tissues were obtained from 37 patients who underwent an open thoracic aortic repair. AD was detected with histological staining. Local congestion and hemorrhage as well as chronic inflammatory cells infiltrations were observed at the dissection. Moreover, extensive disarrangement and disruption of elastic fibers were observed in the medial layer of the aorta with dissection. In summary, our study revealed that the apoptotic rate of vascular SMCs (VSMCs) in the vascular middle layer is higher in the dissected aortas than in the control aortas, suggesting that abnormally elevated apoptosis is correlated with AD pathogenesis. Functional studies of key genes identified in the apoptotic pathways as well as in extracellular matrix would be critical in thoroughly understanding the underlying mechanisms of AD development. Targeting the mediators related to TGF-β1, the Smad family proteins, and caspase 3 or anti-apoptotic agents may provide diagnostic markers and therapeutic targets that could be used to prevent AD.

Report this publication

Statistics

Seen <100 times