Affordable Access

deepdyve-link
Publisher Website

Apoptosis in cultured renal epithelial cells caused by ochratoxin A.

Authors
  • Schwerdt, G
  • Freudinger, R
  • Schuster, C
  • Silbernagl, S
  • Gekle, M
Type
Published Article
Journal
Mycotoxin research
Publication Date
Jun 01, 2000
Volume
16 Suppl 2
Pages
154–157
Identifiers
DOI: 10.1007/BF02940025
PMID: 23605519
Source
Medline
License
Unknown

Abstract

Apoptosis induction in renal epithelial cells caused by exposure to ochratoxin A (OTA) was studied. Nanomolar concentrations of OTA led to activation of caspase 3 with subsequent chromatin condensation and DNA ladder formation, both characteristic for cells undergoing apoptosis. Inhibition of the mitochondrial ATP/ADP carrier prevented OTA induced caspase activation showing that intact mitochondria are necessary for OTA induced apoptosis.

Report this publication

Statistics

Seen <100 times