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Apoptosis in bladder carcinomas detected with monoclonal antibody to single-stranded DNA: relation to cell cycle regulators and survival.

Authors
  • Korkolopoulou, P
  • Konstantinidou, A E
  • Christodoulou, P
  • Patsouris, E
  • Thomas-Tsangli, E
  • Kapralos, P
  • Davaris, P
Type
Published Article
Journal
Urology
Publisher
Elsevier
Publication Date
Sep 01, 2000
Volume
56
Issue
3
Pages
516–520
Identifiers
PMID: 10962336
Source
Medline
License
Unknown

Abstract

An increased apoptotic rate, increased proliferative activity, and decreased p21(Cip1) expression are independently interrelated in TCC. More importantly, the assessment of apoptotic potential appears to be more informative than standard prognosticators in predicting overall survival in patients with muscle-invasive TCC.

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