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Apoptosis associated DNA fragmentation in epileptic brain damage.

Authors
  • Pollard, H
  • Cantagrel, S
  • Charriaut-Marlangue, C
  • Moreau, J
  • Ben Ari, Y
Type
Published Article
Journal
Neuroreport
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
May 09, 1994
Volume
5
Issue
9
Pages
1053–1055
Identifiers
PMID: 8080958
Source
Medline
License
Unknown

Abstract

We have examined the epileptic brain damage generated by intra-amygdaloid administration of kainic acid (KA). In the vulnerable CA3 region of the rat hippocampus, neurones developed apoptotic properties since, (i) their nuclei were positively stained with a selective in situ DNA fragmentation staining method; (ii) DNA cleavage into internucleosome-sized fragments was observed on agarose gels. Our results suggest that epileptic seizures generated in the amygdala by KA trigger apoptotic cell damage in pyramidal CA3 neurones.

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