Apolipoprotein B is a major perforin inhibitor protein in human serum.
- Published Article
- Publication Date
Nov 01, 1991
We purified the high-molecular-weight perforin inhibitor protein from normal human serum using DEAE-cellulose, HPLC-gel filtration and hydroxylapatite chromatography. This protein was shown to be identical to the serum apolipoprotein B-100 in terms of amino acid composition and the sequence of the digested peptides. This inhibitor protein not only inhibits the membrane binding activity of perforin but also the pore insertion activity of membrane-bound perforin.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/1961197