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Apolipoprotein B is a major perforin inhibitor protein in human serum.

Authors
  • Matsuda, K
  • Ishiura, S
  • Koizumi, H
  • Kawasaki, H
  • Arahata, K
  • Sugita, H
Type
Published Article
Journal
Molecular Immunology
Publisher
Elsevier
Publication Date
Nov 01, 1991
Volume
28
Issue
11
Pages
1211–1216
Identifiers
PMID: 1961197
Source
Medline
License
Unknown

Abstract

We purified the high-molecular-weight perforin inhibitor protein from normal human serum using DEAE-cellulose, HPLC-gel filtration and hydroxylapatite chromatography. This protein was shown to be identical to the serum apolipoprotein B-100 in terms of amino acid composition and the sequence of the digested peptides. This inhibitor protein not only inhibits the membrane binding activity of perforin but also the pore insertion activity of membrane-bound perforin.

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