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Aplastic anemia: pathogenesis and treatment.

Authors
  • Bacigalupo, A
  • Piaggio, G
  • Van Lint, M T
  • Figari, O
  • Marmont, A
  • Congiu, M
Type
Published Article
Journal
Onkologie
Publication Date
Jun 01, 1987
Volume
10
Issue
3
Pages
172–173
Identifiers
PMID: 3306537
Source
Medline
License
Unknown

Abstract

Treatment of severe aplastic anemia (SAA) in Europe between 1970 and 1986 is reviewed. 487 patients received an HLA-identical BMT: results are encouraging and currently suggest a 65% survival. However, many patients cannot be offered this procedure because of the absence of an appropriate donor. Forty-five patients were given a non-HLA identical BMT: results are dependent on the degree of mismatch. Immunosuppression (IS) was given to 509 patients: 50% of these survive. Some mechanisms regulating in vitro hematopoiesis are discussed, together with their relevance in the treatment of SAA.

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