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APC/C Cdh1 is required for the termination of chromosomal passenger complex activity upon mitotic exit

Authors
  • Tsunematsu, Takaaki1
  • Arakaki, Rieko1
  • Kawai, Hidehiko2
  • Ruppert, Jan3
  • Tsuneyama, Koichi4
  • Ishimaru, Naozumi1
  • Earnshaw, William C.3
  • Pagano, Michele5, 6, 7
  • Kudo, Yasusei1, 8
  • 1 Tokushima University Graduate School of Biomedical Sciences, Department of Oral Molecular Pathology, Tokushima 770-8504 , (Japan)
  • 2 Hiroshima University Graduate School of Biomedical & Health Sciences, Department of Nucleic Acids Biochemistry, Hiroshima 734-8553 , (Japan)
  • 3 Wellcome Centre for Cell Biology, Institute of Cell Biology, University of Edinburgh, Edinburgh EH9 3BF
  • 4 Tokushima University Graduate School of Biomedical Sciences, Department of Pathology and Laboratory Medicine, Tokushima 770-8504 , (Japan)
  • 5 New York University School of Medicine, Department of Biochemistry and Molecular Pharmacology, New York, NY 10016
  • 6 NYU Perlmutter Cancer Center, New York University School of Medicine, New York, NY 10016
  • 7 Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016
  • 8 Tokushima University Graduate School of Biomedical Sciences, Department of Oral Bioscience, Tokushima 770-8504 , (Japan)
Type
Published Article
Journal
Journal of Cell Science
Publisher
The Company of Biologists
Publication Date
Sep 15, 2020
Volume
133
Issue
18
Identifiers
DOI: 10.1242/jcs.251314
PMID: 32934012
PMCID: PMC7520452
Source
PubMed Central
Keywords
Disciplines
  • Research Article
License
Green

Abstract

Summary: APC/CCdh1 ubiquitylates both borealin, via a non-canonical degron motif, and Aurora B to terminate activity of the CPC in G1 phase. Disruption of this ubiquitylation reduces the efficiency of DNA replication.

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