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Anxiety risk SNPs on chromosome 2 modulate arousal in children in a fear generalization paradigm.

Authors
  • Reinhard, Julia1
  • Drepper, Carsten2
  • Weber, Heike3, 4
  • Schiele, Miriam A5
  • Kneer, Katharina2
  • Mittermeier, Anna2
  • Frey, Lillien2
  • Reif, Andreas4
  • Pauli, Paul6
  • Domschke, Katharina5
  • Deckert, Jürgen3
  • Romanos, Marcel2
  • 1 Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany. [email protected] , (Germany)
  • 2 Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany. , (Germany)
  • 3 Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany. , (Germany)
  • 4 Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital of Frankfurt, Frankfurt, Germany. , (Germany)
  • 5 Department of Psychiatry and Psychotherapy, Medical Center, Faculty of Medicine, University of Freiburg, University of Freiburg, Freiburg, Germany. , (Germany)
  • 6 Department of Psychology (Biological Psychology, Clinical Psychology and Psychotherapy), University of Würzburg, Würzburg, Germany. , (Germany)
Type
Published Article
Journal
European Child & Adolescent Psychiatry
Publisher
Springer-Verlag
Publication Date
Sep 01, 2020
Volume
29
Issue
9
Pages
1301–1310
Identifiers
DOI: 10.1007/s00787-019-01458-7
PMID: 31865460
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Alterations in fear learning/generalization are considered to be relevant mechanisms engendering the development of anxiety disorders being the most prevalent mental disorders. Although anxiety disorders almost exclusively have their first onset in childhood and adolescence, etiological research focuses on adult individuals. In this study, we evaluated findings of a recent meta-analysis of genome-wide association studies in adult anxiety disorders with significant associations of four single nucleotide polymorphisms (SNPs) in a large cohort of 347 healthy children (8-12 years) characterized for dimensional anxiety. We investigated the modulation of anxiety parameters by these SNPs in a discriminative fear conditioning and generalization paradigm in the to-date largest sample of children. Results extended findings of the meta-analysis showing a genomic locus on 2p21 to modulate anxious personality traits and arousal ratings. These SNPs might, thus, serve as susceptibility markers for a shared risk across pathological anxiety, presumably mediated by alterations in arousal.

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