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The ‘antiviral state’ has shaped the CpG composition of the vertebrate interferome to avoid self-targeting

Authors
  • Sauter, Daniel
  • Kirchhoff, Frank
Type
Published Article
Journal
PLoS Biology
Publisher
Public Library of Science
Publication Date
Sep 08, 2021
Volume
19
Issue
9
Identifiers
DOI: 10.1371/journal.pbio.3001353
PMID: 34495970
PMCID: PMC8425523
Source
PubMed Central
Disciplines
  • Biology and Life Sciences
  • Microbiology
  • Virology
  • Virus Effects on Host Gene Expression
License
Unknown

Abstract

Viruses may not only affect our daily lives but also shape our genome evolution. A recent study shows that the zinc-finger antiviral protein (ZAP) drives CpG suppression in a biased manner. Genes involved in the defense against viral invaders are particularly CpG suppressed to avoid self-targeting and to promote an effective immune response.

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