The ‘antiviral state’ has shaped the CpG composition of the vertebrate interferome to avoid self-targeting
- Authors
- Type
- Published Article
- Journal
- PLoS Biology
- Publisher
- Public Library of Science
- Publication Date
- Sep 08, 2021
- Volume
- 19
- Issue
- 9
- Identifiers
- DOI: 10.1371/journal.pbio.3001353
- PMID: 34495970
- PMCID: PMC8425523
- Source
- PubMed Central
- Disciplines
- License
- Unknown
Abstract
Viruses may not only affect our daily lives but also shape our genome evolution. A recent study shows that the zinc-finger antiviral protein (ZAP) drives CpG suppression in a biased manner. Genes involved in the defense against viral invaders are particularly CpG suppressed to avoid self-targeting and to promote an effective immune response.
