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Antiviral Effector RTP4 Bats against Flaviviruses

Authors
  • Nielsen, Joshua R.1
  • Lazear, Helen M.1
  • 1 Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Type
Published Article
Journal
Immunity
Publication Date
Dec 15, 2020
Volume
53
Issue
6
Pages
1133–1135
Identifiers
DOI: 10.1016/j.immuni.2020.11.019
PMID: 33326764
PMCID: PMC7834619
Source
PubMed Central
Disciplines
  • Preview
License
Unknown

Abstract

Bats harbor diverse viruses and manifest distinct antiviral immune responses. Recently in Cell Host & Microbe , Boys et al. demonstrated that bat receptor transporter protein 4 (RTP4) is an innate antiviral effector that inhibits flavivirus replication, revealing an evolutionary arms race between flaviviruses and their hosts.

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