Affordable Access

Publisher Website

Antitumor promoting potential of selected phytochemicals derived from spices: a review.

Authors
Type
Published Article
Journal
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)
Publication Date
Volume
21
Issue
2
Pages
205–215
Identifiers
DOI: 10.1097/CEJ.0b013e32834a7f0c
PMID: 21876437
Source
Medline

Abstract

Carcinogenesis is a multistep process exhibiting deregulation in multiple cellular signaling pathways. Therefore, specific agent based treatments that target only one pathway usually fail in cancer therapy. The combination treatments using chemotherapeutic agents with distinct molecular mechanisms are considered more promising for higher efficacy; however, using multiple agents contributes to added toxicity. However, the in-vitro and in-vivo studies in the last few decades have demonstrated that some phytochemicals derived from 'natural products' such as fruits, vegetables and certain spices, referred to as chemopreventive agents, including capsaicin, trans-anethole, thymoquinone, diosgenin, allicin, can not only reduce the risk of acquiring specific cancer but also have been shown to suppress cancer cell proliferation, inhibit growth factor signaling pathways, induce apoptosis, inhibit nuclear factor-κB, AP-1, Akt, MAPK, Wnt, Notch, p53, AR, ER, and JAK-STAT, etc., activation pathways, inhibit angiogenesis, suppress the expression of antiapoptotic proteins, and inhibit cyclooxygenase-2. This study describes the above active components of some of the major spices, their mechanisms of action and their potential in prevention of various cancers.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments