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Antitumor-promoting activities of hydrolyzable tannins in mouse skin.

Authors
  • Gali, H U
  • Perchellet, E M
  • Klish, D S
  • Johnson, J M
  • Perchellet, J P
Type
Published Article
Journal
Carcinogenesis
Publication Date
Apr 01, 1992
Volume
13
Issue
4
Pages
715–718
Identifiers
PMID: 1576722
Source
Medline
License
Unknown

Abstract

Ellagic acid and gallic acid and its derivatives, applied topically to female CF-1 mice 20 min before each 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment inhibit the inductions of epidermal ornithine decarboxylase activity, hydroperoxide production and DNA synthesis caused by this potent tumor promoter in relation with their abilities to inhibit the promotion of skin papillomas and carcinomas in the two-step initiation-promotion protocol. Because of its potency against TPA promotion, tannic acid, which is already known to inhibit tumor initiation, may inhibit the multistage process of carcinogenesis.

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