Affordable Access

Access to the full text

Anti-thymocyte globulin, cyclosporin A and granulocyte colony-stimulating factor for severe aplastic anaemia complicating paediatric liver transplantation

Authors
  • Hadzic, N.1
  • Layton, M.2
  • Heaton, N. D.3
  • Rela, M.3
  • Baker, A. J.1
  • Mieli-Vergani, G.1
  • 1 Department of Child Health, King's College Hospital, Denmark Hill, London SE5 9RS, UK, Tel.: 44-171-3463214, Fax: 44-171-3463564, DK
  • 2 Department of Haematological Medicine, King's College Hospital, London, UK, GB
  • 3 Liver Transplant Surgical Service, King's College Hospital, London, UK, GB
Type
Published Article
Journal
European Journal of Pediatrics
Publisher
Springer-Verlag
Publication Date
Jan 01, 1998
Volume
157
Issue
2
Pages
107–108
Identifiers
DOI: 10.1007/s004310050779
Source
Springer Nature
Keywords
License
Yellow

Abstract

We describe a sustained trilineage haematopoietic response to intensified immunosuppressive therapy with anti-thymocyte globulin, cyclosporin A and recombinant human granulocyte colony-stimulating factor in a 4-year-old girl, who developed severe aplastic anaemia after orthotopic liver transplantation for fulminant liver failure induced by non A-E hepatitis. The outcome was successful and allows the following. Conclusion Intense immunosuppression in combination with haemopoetic growth factors and antimicrobial prophylaxis should be considered as first line therapy in severe aplastic anaemia after orthotopic liver trans plantation.

Report this publication

Statistics

Seen <100 times