Antithrombin reduces shedding of the endothelial glycocalyx following ischaemia/reperfusion.
- Authors
- Type
- Published Article
- Journal
- Cardiovascular Research
- Publisher
- Oxford University Press
- Publication Date
- Jul 15, 2009
- Volume
- 83
- Issue
- 2
- Pages
- 388–396
- Identifiers
- DOI: 10.1093/cvr/cvp097
- PMID: 19307232
- Source
- Medline
- License
- Unknown
Abstract
Antithrombin preserves the endothelial glycocalyx, sustaining the vascular barrier function and reducing interstitial oedema. The potentiated effect of colloid in these hearts suggests that the prevention of shedding should be of functional benefit also in vivo.