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Antithrombin reduces shedding of the endothelial glycocalyx following ischaemia/reperfusion.

Authors
  • Chappell, Daniel
  • Jacob, Matthias
  • Hofmann-Kiefer, Klaus
  • Rehm, Markus
  • Welsch, Ulrich
  • Conzen, Peter
  • Becker, Bernhard F
Type
Published Article
Journal
Cardiovascular Research
Publisher
Oxford University Press
Publication Date
Jul 15, 2009
Volume
83
Issue
2
Pages
388–396
Identifiers
DOI: 10.1093/cvr/cvp097
PMID: 19307232
Source
Medline
License
Unknown

Abstract

Antithrombin preserves the endothelial glycocalyx, sustaining the vascular barrier function and reducing interstitial oedema. The potentiated effect of colloid in these hearts suggests that the prevention of shedding should be of functional benefit also in vivo.

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