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Antithrombin-III without concomitant heparin improves endotoxin-induced acute lung injury rats by inhibiting the activation of mitogen-activated protein kinase.

Authors
  • Sun, Hui-ming
  • Hong, Ling-zhi
  • Shen, Xiao-kun
  • Lin, Xin-qing
  • Song, Yong
  • Shi, Yi
Type
Published Article
Journal
Chinese medical journal
Publication Date
Oct 20, 2009
Volume
122
Issue
20
Pages
2466–2471
Identifiers
PMID: 20079161
Source
Medline
License
Unknown

Abstract

AT-III without concomitant heparin inhibited the activation of ERK1/2 and P38 MAPK, down-regulated the levels of downstream cytokines TNF-alpha and IL-6, relieved endothelial permeability, and improved the ALI in endotoxin-induced rats. It might be helpful to administrate AT-III alone, not with concomitant heparin, to those patients with ALI and sepsis.

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