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Antithrombin deficiency increases thrombin activity after prolonged cardiopulmonary bypass.

Authors
  • Sniecinski, Roman
  • Szlam, Fania
  • Chen, Edward P
  • Bader, Stephen O
  • Levy, Jerrold H
  • Tanaka, Kenichi A
Type
Published Article
Journal
Anesthesia & Analgesia
Publisher
Ovid Technologies (Wolters Kluwer) - Anesthesia & Analgesia
Publication Date
Mar 01, 2008
Volume
106
Issue
3
Identifiers
DOI: 10.1213/ane.0b013e3181608f7c
PMID: 18292407
Source
Medline
License
Unknown

Abstract

Plasma AT activity is severely decreased after CPB with DHCA. Our data suggest that the administration of coagulation factor components without AT repletion may lead to excessive thrombin generation, which clinically, may potentially lead to a hypercoagulable state.

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