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Antisecretory effects of two new histamine H2-receptor antagonists.

Authors
  • Bickel, M
  • Herling, A W
  • Rising, T J
  • Wirth, K
Type
Published Article
Journal
Arzneimittel-Forschung
Publication Date
Sep 01, 1986
Volume
36
Issue
9
Pages
1358–1363
Identifiers
PMID: 2878669
Source
Medline
License
Unknown

Abstract

N-(3-[3-(1-Piperidinylmethyl)phenoxy]propyl)acetoxyaceta mide hydrochloride (Hoe 760) and N-(3-[3-(1-piperidinylmethyl)phenoxy]propyl)glycolamine hydrochloride (Hoe 062) are highly specific H2-receptor antagonists. The compounds are equipotent after intragastrical or intravenous administration. The antagonists inhibited gastric acid secretion in the rat induced by all stimuli tested, carbachol, desglugastrin and histamine. In the Heidenhain pouch dog whose gastric acid secretion was stimulated by food or histamine the two receptor blockers proved to be 4-6 times more potent inhibitors than cimetidine.

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