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Antirheumatic Drug Intake Influence on Occurrence of COVID-19 Infection in Ambulatory Patients with Immune-Mediated Inflammatory Diseases: A Cohort Study

  • Guillaume, Debellemanière1
  • Magalie, Bouvet1
  • Sina, Elahi1
  • Imène, Salah-Mabed1
  • Frédéric, Vayr1
  • Mathieu, Dubois1
  • Aurore, Muselier1
  • Yoni, Gozlan1
  • Emma, Elbaz1
  • Charlotte, Badatcheff1
  • Laura, Fabre1
  • Alain, Saad1
  • Steven, Nahaisi1
  • Pierre, Zeboulon1
  • Jean-Luc, Febbraro1
  • Romain, Courtin1
  • Alice, Grise-Dulac1
  • Adrien, Mazharian1
  • Wassim, Ghazal1
  • Pierre-Emmanuel, Remongin1
  • And 5 more
  • 1 Adolphe de Rothschild Foundation Hospital,
  • 2 Jean Minjoz University Hospital,
  • 3 Perpignan Hospital, Perpignan, France
Published Article
Rheumatology and Therapy
Springer Healthcare
Publication Date
Sep 16, 2021
DOI: 10.1007/s40744-021-00373-1
PMID: 34529226
PMCID: PMC8444183
PubMed Central
  • Brief Report


Introduction We aimed to study the prevalence of a history of COVID-19 infection among patients suffering from systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjögren’s syndrome (SjS) or psoriatic arthritis (PsA), and the potential influence of long-term hydroxychloroquine (HCQ) intake. Methods We performed an observational monocentric cohort study at the Adolphe de Rothschild Foundation Hospital ophthalmology division (Paris, France). Electronic medical records (EMR) data were searched for keywords associated with SLE, RA, SjS, or PsA. Patients were contacted by phone and were interviewed using a standardized questionnaire. The primary outcome was the occurrence of a positive COVID-19 test result during the study period. We determined the adjusted association between various antirheumatic drugs intake, COVID-19 risk factors, and occurrence of COVID-19 using a logistic regression model. This study is registered on (Identifier: NCT04345159). Results Patients were recruited between Apr 17, 2020, and Apr 30, 2020 and were recontacted between Oct 6, 2020, and Nov 2, 2020. A total of 569 patients were included, of whom 459 patients were eligible for data analysis. One hundred and eighty-one patients were treated with long-term HCQ and 18 patients had tested positive for COVID-19. No antirheumatic drug intake, including HCQ intake, was significantly associated with an increased or decreased risk of developing COVID-19 infection. Conclusions No antirheumatic drug intake was associated with an increased or decreased risk of developing COVID-19 infection in our cohort of patients suffering from immune-mediated inflammatory diseases.

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