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Antiproliferative effects of a product isolated from the gorgonian Rumphella aggregata.

Authors
  • Nourry, M
  • Urvois, P A
  • Tomasoni, C
  • Biard, J F
  • Verbist, J F
  • Roussakis, C
Type
Published Article
Journal
Anticancer research
Publication Date
Jan 01, 1999
Volume
19
Issue
3A
Pages
1881–1885
Identifiers
PMID: 10470131
Source
Medline
License
Unknown

Abstract

A fraction isolated from the gorgonian Rumphella aggregata (Plexauridae) was studied vitro on asynchronous cells of a human non-small-cell-bronchopulmonary-carcinoma line (NSCLC-N6). Cell growth appeared to be inhibited in the Gl phase of the cell cycle, and kinetic studies in pretreated cells showed that this growth arrest was irreversible. These events seem to show a terminal maturation induced by this new product.

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