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Antiproliferative effect of isopentenylated coumarins on several cancer cell lines.

Authors
  • Kawaii, S
  • Tomono, Y
  • Ogawa, K
  • Sugiura, M
  • Yano, M
  • Yoshizawa, Y
  • Ito, C
  • Furukawa, H
Type
Published Article
Journal
Anticancer research
Publication Date
Jan 01, 2001
Volume
21
Issue
3B
Pages
1905–1911
Identifiers
PMID: 11497276
Source
Medline
License
Unknown

Abstract

33 coumarins, mainly the simple isopentenylated coumarins and derived pyrano- and furanocoumarins, were examined for their antiproliferative activity towards several cancer and normal human cell lines. The pyrano- and furanocoumarins showed strong activity against the cancer cell lines, whereas they had weak antiproliferative activity against the normal human cell lines. The decreasing rank order of potency was osthenone (10), clausarin (25), clausenidin (26), dentatin (24), nordentatin (23), imperatorin (29), seselin (27), xanthyletin (21), suberosin (17), phebalosin (8) and osthol (12). The structure-activity relationship established from the results revealed that the 1,1-dimethylallyl and isopentenyl groups have an important role for antiproliferative activity.

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