Affordable Access

Access to the full text

Antiproliferative and proapoptotic activities of 4-hydroxybenzoic acid-based inhibitors of histone deacetylases

Authors
Type
Published Article
Journal
Cancer Letters
Publisher
Elsevier
Publication Date
Feb 24, 2014
Volume
343
Issue
1
Pages
146–146
Identifiers
DOI: 10.1016/j.canlet.2013.09.026
Source
LBMCC
Keywords
License
Green

Abstract

Histone acetyltransferases (HATs) and histone deacetylases (HDACs) regulate cellular processes by modifying the acetylation status of many proteins. Pathologically altered HDAC activity contributes to cancer development and thus characterization of novel acetylation modulators is important for future anti-cancer therapies. In this study, we identified three novel 4-hydroxybenzoic acid derivatives as pan-HDAC inhibitors that increased protein acetylation levels, arrested cell cycle progression and triggered apoptotic cell death, without affecting viability of normal cells. Our data support the potential of 4-hydroxybenzoic acid derivatives as pan-HDAC inhibitors with anticancer properties.

Report this publication

Statistics

Seen 550 times