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Antioxidant supplementation and risk of incident melanomas: results of a large prospective cohort study.

Authors
  • Asgari, Maryam M
  • Maruti, Sonia S
  • Kushi, Lawrence H
  • White, Emily
Type
Published Article
Journal
Archives of Dermatology
Publisher
American Medical Association
Publication Date
Aug 01, 2009
Volume
145
Issue
8
Pages
879–882
Identifiers
DOI: 10.1001/archdermatol.2009.176
PMID: 19687417
Source
Medline
License
Unknown

Abstract

Cox proportional hazards regression models were used to estimate multivariable relative risks (RRs) and 95% confidence intervals (CIs) for multivitamin, supplemental selenium, and supplemental beta carotene use. After adjusting for melanoma risk factors, we did not detect a significant association between multivitamin use and melanoma risk in women (RR, 1.14; 95% CI, 0.78-1.66) or in men (RR, 1.09; 95% CI, 0.83-1.43). Moreover, we did not observe increased melanoma risk with the use of supplemental beta carotene (RR, 0.87; 95% CI, 0.48-1.56) or selenium (RR, 0.98; 95% CI, 0.69-1.41) at doses comparable with those of the SUVIMAX study. Conclusion Antioxidants taken in nutritional doses do not seem to increase melanoma risk.

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