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Antioxidant multi-walled carbon nanotubes by free radical grafting of gallic acid: new materials for biomedical applications.

Authors
  • Cirillo, Giuseppe1
  • Hampel, Silke
  • Klingeler, Rüdiger
  • Puoci, Francesco
  • Iemma, Francesca
  • Curcio, Manuela
  • Parisi, Ortensia Ilaria
  • Spizzirri, Umile Gianfranco
  • Picci, Nevio
  • Leonhardt, Albrecht
  • Ritschel, Manfred
  • Büchner, Bernd
  • 1 Department of Pharmaceutical Sciences, University of Calabria, Arcavacata di Rende (CS), Italy. [email protected] , (Italy)
Type
Published Article
Journal
The Journal of pharmacy and pharmacology
Publication Date
Feb 01, 2011
Volume
63
Issue
2
Pages
179–188
Identifiers
DOI: 10.1111/j.2042-7158.2010.01211.x
PMID: 21235581
Source
Medline
Language
English
License
Unknown

Abstract

To prove the possibility of covalently functionalizing multi-walled carbon nanotubes (CNTs) by free radical grafting of gallic acid on their surface with the subsequent synthesis of materials with improved biological properties evaluated by specific in-vitro assays. Antioxidant CNTs were synthesized by radical grafting of gallic acid onto pristine CNTs. The synthesis of carbon nanotubes was carried out in a fixed-bed reactor and, after the removal of the amorphous carbon, the grafting process was performed. The obtained materials were characterized by fluorescence and Fourier transform infrared spectroscopy (FT-IR) analyses. After assessment of the biocompatibility and determination of the disposable phenolic group content, the antioxidant properties were evaluated in terms of total antioxidant activity and scavenger ability against 2,2'-diphenyl-1-picrylhydrazyl (DPPH), hydroxyl and peroxyl radicals. Finally the inhibition activity on acetylcholinesterase was evaluated. The covalent functionalization of CNTs with gallic acid was confirmed and the amount of gallic acid bound per g of CNTs was found to be 2.1±0.2 mg. Good antioxidant and scavenging properties were recorded in the functionalized CNTs, which were found to be able to inhibit the acetylcholinesterase with potential improved activity for biomedical and pharmaceutical applications. For the first time, a free radical grafting procedure was proposed as a synthetic approach for the covalent functionalization of CNTs with an antioxidant polyphenol. © 2010 The Authors. JPP © 2010 Royal Pharmaceutical Society.

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