Affordable Access

[Antioxidant effect of metallothioneins in acute bromobenzene poisoning in mice].

Authors
  • Koterov, A N
  • Kon', I Ia
Type
Published Article
Journal
Ukrainskiĭ biokhimicheskiĭ zhurnal (1978)
Publication Date
Jan 01, 1995
Volume
67
Issue
5
Pages
99–105
Identifiers
PMID: 8830445
Source
Medline
License
Unknown

Abstract

An increase in the content of malondialdehyde (MDA) and endogenous metallothioneins (MT) in the liver of mice 1 day after intraperitoneal injection of bromobenzene (0.5-2 g/kg) has been found. An exogenic zinc-MT polymer injected to mice decreases the basal and xenobiotic-induced MDA level in the liver and blood plasma and decreases the acute toxicity of bromobenzene. The mixture modelling zinc-MT composition (albumin, cysteine and zinc) possesses no such properties. A conclusion is made that the protective effect is specific for the MT structure and is induced by antioxidant properties of MT.

Report this publication

Statistics

Seen <100 times