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Antioxidant activity of Glossogyne tenuifolia.

Authors
  • Wu, Ming-Jiuan
  • Huang, Chia-Lin
  • Lian, Tzi-Wei
  • Kou, Mei-Chuan
  • Wang, Lisu
Type
Published Article
Journal
Journal of agricultural and food chemistry
Publication Date
Aug 10, 2005
Volume
53
Issue
16
Pages
6305–6312
Identifiers
PMID: 16076111
Source
Medline
License
Unknown

Abstract

Glossogyne tenuifolia is a native traditional anti-inflammatory herb in Taiwan. It has previously been shown that the ethanol extract of G. tenuifolia (GT) inhibited the LPS-induced inflammatory mediator release from murine macrophage cell line and human whole blood. In the present work, the ethanol extracts of G. tenuifolia and its major constituent, luteolin-7-glucoside, were shown to be scavengers of 1,1-diphenyl-2-picrylhydrazyl, superoxide, and hydroxyl radicals. Moreover, copper-induced low-density lipoprotein oxidation was suppressed by GT and luteolin-7-glucoside as measured by decreased formation of malondialdehyde and conjugated diene as well as reduced electrophoretic mobility. GT and luteolin-7-glucoside were also against N-formyl-methionyl-leucyl-phenylalanine-induced reactive oxygen species (ROS) production in human polymorphonuclear neutrophils and peripheral blood mononuclear cells. In summary, these data indicated that GT is a potential ROS scavenger and may prevent atherosclerosis via inhibiting LDL oxidation or ROS production in human leukocytes. Moreover, luteolin-7-glucoside may serve as the active principal of GT.

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