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Antioxidant activity of butane type lignans, secoisolariciresinol, dihydroguaiaretic acid, and 7,7'-oxodihydroguaiaretic acid.

Authors
  • Yamauchi, Satoshi
  • Masuda, Toshiya
  • Sugahara, Takuya
  • Kawaguchi, Yuya
  • Ohuchi, Maya
  • Someya, Tatsushi
  • Akiyama, Jun
  • Tominaga, Shiori
  • Yamawaki, Manami
  • Kishida, Taro
  • Akiyama, Koichi
  • Maruyama, Masafumi
Type
Published Article
Journal
Bioscience Biotechnology and Biochemistry
Publisher
Informa UK (Taylor & Francis)
Publication Date
Nov 01, 2008
Volume
72
Issue
11
Pages
2981–2986
Identifiers
PMID: 18997397
Source
Medline
License
Unknown

Abstract

The antioxidant activity of butane-type lignans was evaluated. Secoisolariciresinol (SECO) and dihydroguaiaretic acid (DGA) showed higher radical scavenging activity than that of 7,7'-dioxodihydroguaiaretic acid (ODGA). SECO and DGA inhibited the oxidation of unsaturated fatty acid. Both enantiomers of DGA were also lipoxygenase inhibitors, but neither enantiomer of SECO inhibited the lipoxygenase activity.

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