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Antinociceptive effect of chronic lithium on visceral hypersensitivity in a rat model of diarrhea-predominant irritable bowel syndrome: The role of nitric oxide pathway.

Authors
  • Shamshiri, Hosein
  • Paragomi, Pedram
  • Paydar, Mehrak Javadi
  • Moezi, Leila
  • Bahadori, Moslem
  • Behfar, Behnaz
  • Ardalan, Farid A
  • Dehpour, Ahmad R
Type
Published Article
Journal
Journal of Gastroenterology and Hepatology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Apr 01, 2009
Volume
24
Issue
4
Pages
672–680
Identifiers
DOI: 10.1111/j.1440-1746.2008.05652.x
PMID: 19032458
Source
Medline
License
Unknown

Abstract

The results indicate the antinociceptive property of chronic lithium on visceral hypersensitivity. As this effect was lowered by NOS inhibitors, NO might play a role in the protective effect of lithium to some extent.

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