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Antimyosin scintigraphy and immunohistologic analysis of endomyocardial biopsy in patients with clinically suspected myocarditis--evidence of myocardial cell damage and inflammation in the absence of histologic signs of myocarditis.

Authors
  • Kühl, U
  • Lauer, B
  • Souvatzoglu, M
  • Vosberg, H
  • Schultheiss, H P
Type
Published Article
Journal
Journal of the American College of Cardiology
Publisher
Elsevier
Publication Date
Nov 01, 1998
Volume
32
Issue
5
Pages
1371–1376
Identifiers
PMID: 9809950
Source
Medline
License
Unknown

Abstract

Antimyosin scintigraphy often shows myocyte injury in patients with clinically suspected myocarditis. Histologic analysis of the endomyocardial biopsy alone is often negative, but additional immunohistologic analysis of the endomyocardial biopsy frequently provides evidence of myocardial inflammation in these patients. With immunohistologic analysis as the reference method, antimyosin scintigraphy has a high specificity but a lower sensitivity for the detection of myocarditis.

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