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Antimutagenic and antioxidant activities of crown compounds in comparison with the effects of garlic extract.

Authors
  • Zasukhina, G D
  • Vasil'eva, I M
  • Mikhal'chik, E S
  • Durnev, A D
  • Gromov, S P
  • Fedorova, O A
  • Alfimov, M V
Type
Published Article
Journal
Bulletin of experimental biology and medicine
Publication Date
Mar 01, 2003
Volume
135
Issue
3
Pages
261–264
Identifiers
PMID: 12802397
Source
Medline
License
Unknown

Abstract

Antimutagenic activity of N-carboxyalkyl derivatives of aza- and benzoazacrown compounds was revealed and antimutagenic activity of garlic extract was confirmed. Specific genoprotective effect of crown compounds towards the effects of various mutagens was demonstrated. The antimutagenic effect of these compounds was not realized via antioxidant mechanisms, while the protective effect of garlic extract was associated with its antioxidant and reparative activities.

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